Taylor Tomlinson began performing comedy when she was 16, after her father signed her up for a stand-up class. She performed in church basements, school venues, and coffee shops. She became a top 10 finalist on the ninth season of NBC's Last Comic Standing in 2015, and was named one of the "Top 10 Comics to Watch" by Variety at the 2019 Just for Laughs Festival. She has appeared on The Tonight Show, Conan, and various Comedy Central productions. She developed a sitcom for ABC in 2017, but it was not picked up for a pilot. She performed a 15-minute set on an episode of the Netflix stand-up series The Comedy Lineup in 2018.
Tomlinson's first Netflix stand-up special, Quarter-Life Crisis, premiered in March 2020. Later that year, she toured with fellow comedian Whitney Cummings on the Codependent Tour. She was also part of the podcast Self-Helpless with fellow comedians Kelsey Cook and Delanie Fischer that year. In 2021, she started her own podcast called Sad in the City. She was placed on the Forbes 30 Under 30 list in December 2021. Her second Netflix stand-up special, Look At You, premiered in March 2022.